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KMID : 0895820160260010001
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Journal of Oriental Rehabilitation Medicine
2016 Volume.26 No. 1 p.1 ~ p.11
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Effects of Hyulboochucke-tang on the Collagenase-Induced Intracerebral Hemorrhage in Rats
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Kim Yong
Seo Il-Bok
Kim Soon-Joong
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Abstract
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Objectives : The purpose of this study was to investigate the effect of Hyulboochucke- tang on the collagenase induced intracerebral hemorrhage in white rats.
Methods : To identify the effect of the Hyulboochucke-tang on intracerebral hemorrhage, intracerebral hemorrhage was induced in the right caudate nuclei of white rats. For normal group (n=12) and comparative group (n=12), saline was dosed, and vaccum evaporated Hyulboochucke-tang extract was dosed to treatment group (n=12), 3 and 10 days after the collagenase injection, the body weight, the brain weight, the size of hematoma, the size of the area of malacia, the number of apoptotic cell and the change in pathological histology were observed.
Results : 3 days after the injection, the brain weight(g) was considerably decreased in treatment group (n=12) compared to comparative group (n=12). The brain weight after 10 days of the injection was also considerably decreased in treatment group (n=6) against comparative group (n=6). The cross section(mm) of cerebral malacia after 10 days of the in-jection was considerably decreased in treatment group (n=6) compared to comparative group (n=6). The number of apoptotic cell in normal intracerebral around the area of mala-cia did not show considerable change between treatment group and comparative group. 12 days after the injection, the multiplication of gitter cells, astrocyte and newly formed ca-pillaries around the area of malacia was distinct.
Conclusions : On the basis of these results, We sugggest that Hyulboochucke-tang con-trols swelling caused by hemorrhage and contributes to absorption of hematoma by multi-plication of newly formed capillaries and recovery of damaged cerebral tissue by multi-plication of gitter cells and astrocyte.
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KEYWORD
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Hyulboochucke-tang (Xuefuzhuyu-Tang), Intracerebral Hemorrhage, Collagenase, Brain edema
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